The Maserati Mistral Spyder was introduced one year after the coupé version, at the 1964 Geneva motor show. The Mistral’s supremely elegant design was further enhanced by the convertible form. The styling came courtesy of Giovanni Michelotti’s pen, and Vignale was the coachbuilder. It was offered with a choice of either the 3.5 liter engine from the 3500 GT or the 3.7 liter variant, to which a further enhanced 4 liter unit was added a couple years later (see separate descriptions).

In the first year of production the car was still called simply “2 Posti” spyder before it was christened the more poetic Mistral. Even in 3.5 liter guise performance was much more than simply poetic, as a healthy 235 hp was on tap. Mistral roadsters were predominately steel-bodied, with the hood, doors and trunk lid in alloy. A very rare optional hardtop was designed for the car and was also produced in light alloy.